Mandarin (Citrus reticulata) has a long history in traditional Chinese medicine (TCM) and other Asian herbal traditions, where its peel, known as "chen pi," is commonly used in remedies for respiratory issues, including colds and coughs. The use of mandarin or its peel for preventing colds is based primarily on traditional knowledge rather than rigorous scientific evidence. In TCM, chen pi is believed to regulate qi (energy), resolve phlegm, and support digestive and respiratory health. It is often included in herbal formulas aimed at easing symptoms of colds, such as congestion and cough. From a scientific perspective, mandarin peel contains flavonoids, vitamin C, and essential oils (such as limonene), which have some antioxidant and mild anti-inflammatory properties. However, there are no robust clinical trials demonstrating that mandarin or its peel can prevent colds in humans. Most supporting evidence comes from in vitro or animal studies that are not directly applicable to cold prevention in people. Thus, while the traditional use is well-documented, scientific validation is limited and does not currently support mandarin as an effective preventive agent against the common cold.