Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Atractylone is a sesquiterpene compound found in Atractylodes species, particularly Atractylodes macrocephala, which is a key herb in Traditional Chinese Medicine (TCM). The use of atractylone-containing herbs for the prevention and treatment of colds is primarily rooted in traditional practices rather than robust scientific evidence. In TCM, Atractylodes is considered to "strengthen the spleen" and "dispel dampness," which are believed to enhance overall immunity and resistance to external pathogens, including those causing colds. Historical texts and modern TCM practitioners often recommend formulas containing Atractylodes for individuals prone to frequent colds, especially those characterized as having a "deficient constitution."

Scientific research on atractylone itself is limited with regard to colds. Some in vitro and animal studies suggest that atractylone and related compounds may possess immunomodulatory and anti-inflammatory properties, but direct evidence for efficacy in preventing or treating the common cold in humans is lacking. Clinical trials specifically examining atractylone or Atractylodes extracts for cold prevention are sparse or of low methodological quality. Thus, while its use for this purpose is well-established in tradition, contemporary scientific validation remains limited.

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