Evidence supporting the use of: Vitamin D
For the health condition: Colds (antiviral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D is scientifically investigated for its potential role in supporting immune function and reducing the risk or severity of respiratory tract infections, including the common cold. Numerous observational studies have indicated that individuals with low vitamin D levels are more susceptible to respiratory infections. The biological rationale is that vitamin D modulates both innate and adaptive immune responses. It promotes the production of antimicrobial peptides such as cathelicidin, which have antiviral and antibacterial properties, in respiratory epithelial cells.

Randomized controlled trials (RCTs) and meta-analyses have yielded mixed but generally supportive results. A 2017 individual participant data meta-analysis published in BMJ found that vitamin D supplementation reduced the risk of acute respiratory infections, particularly in individuals with existing vitamin D deficiency. However, some studies have not found significant benefits in reducing the incidence or duration of colds in otherwise healthy individuals with adequate vitamin D status.

Overall, while vitamin D is not a cure for the common cold, there is moderate-quality scientific evidence (rating: 3 out of 5) that supplementation may help reduce the risk and possibly the severity of respiratory viral infections, especially in those who are deficient. Its antiviral effects appear to be mediated via immune system modulation rather than direct antiviral activity. Supplementation is generally considered safe when used within recommended dosages.

More about vitamin D
More about Colds (antiviral)

Other ingredients used for Colds (antiviral)

Acacetin
Agastache
AHCC
Allicin
Alliin
Allium tuberosum
Allspice
Allyl isothiocyanate
Allyl sulfide
Aloe vera
alpha-terpineol
alpinia galangal
amentoflavone
anamu
Andrographis
andrographolide
anthocyanins
apigenin
arabinogalactan
Asam gelugor
ash
Asteraceae
atractylone
Aureobasidium pullulans
Autumn elaeagnus
baicalin
Baikal Skullcap
balsam
Baphicacanthus cusia
Basidiomycota
basil
Bassia scoparia
bee hive
bee products
bee propolis
berry
beta-pinene
Bidens pilosa
bilberry
bishop\'s weed
bitter grass
black cumin
black currant
black galingale
black garlic
black nightshade
black seed
blueberry
Bombax
borneol
Broussonetia
buckthorn
caffeic Acid
Camellia sinensis
capillary artemisia
carrageenan
carvacrol
cat's claw
catechins
Celosia
Chinese mountain ant
Chinese raisintree
Chondrus
chrysanthemum
cinnamaldehyde
cinnamon
Cistus
citron
Citrus
citrus bioflavonoids
Clerodendrum trichotomum
clove
coconut
commiphora
common madia
coriolus mushroom
costus
cowherb
curry leaf
David\'s milkberry
deoxyandrographolides
Echinacea
echinacea purpurea
Elder
elderberry
epigallocatechin gallate (EGCG)
essential oil blend
European Elder
flavones
flavonoids
flavonones
forsythia
fruit
fulvic acid
fungus
Galangal
Gallesia
gallotannin
gamma-terpinene
ganoderma
garlic
garlic bulb
ginger
glyceryl monolaurate
Glycyrrhetinic acid
Glycyrrhizin
goji berry
goldthread
green tea
Hedyotis
Himalaya berry
honey
honey loquat syrup
honeysuckle
Houttuynia
hyssop
Indian frankincense
Indian kinotree
indigo leaves
Isatis
knotweed
labrador tea
Lactoferrin
Lactoperoxidase
Laggera pterodonta
lauric acid
lemon
lemongrass
lichen
licorice root
Ligusticum
ligustilides
Ligustrum
Litsea
liverwort
Lomatium
luffa
luteolin
mangostin
Mastic gum
Melia
Mineral ascorbate
Monolaurin
Monoterpenes
Morinda
Morus
Mugwort
Mushroom
Naphthoquinones
Neem tree
Neoandrographolides
nut grass
Nymphaea nouchali
oregano
oriental arborvitae
Osha
Osmanthus
Oxystelma
papaya
Paris polyphylla
Patrinia
pau d'arco
perilla
Petiveria
Phaeophyceae
Phellodendron
phellodendron amurense
phenolic compounds
Phenylpropanoids
Phyllanthus
pineapple
Piper nigrum
Polygonum
pomegranate
Propolis
quercetin
ravinsara
resveratrol
rhizome
rosemary
Salvia
Sambucus nigra
Sandalwood
saponins
schizonepeta
Sesquiterpenes
shiitake mushroom
Shikimic Acid
Shogaol
Smartweed
Solanaceae
Solanum indicum
Sophora
soursop
spirulina
Tagetes
Tamaricaceae
Tayuya
Tea
Terpenoids
Theaflavin
Thiosulfinate
thyme
Thymus
Trametes
Triterpenes
turmeric
Verbascoside
Viola
Violet
Visnea Mocanera
vitamin C
vitamin D
Wasabi
Waterhyssop
White Tea
xanthium (cockleburs)
Xanthorrhizol
zanthoxylum
Zinc
Zingiberene

Other health conditions supported by vitamin D

Allergies (food)
Alzheimer's Disease
Amenorrhea
Anorexia
Apathy
Arrhythmia
Arthritis
Autism
Autoimmune Disorders
Backache
Birth Defects (prevention)
Body Building
Broken Bones
Calcium Deficiency
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Celiac Disease
Chronic Obstructive Pulmonary Disorder
Colds (antiviral)
Colds (general)
Colds (prevention)
Colds (with fever)
Concentration (poor)
Concussions
Confusion
Congestive Heart Failure
Contagious Diseases
Convalescence
Convulsions
Cramps (menstrual)
Cramps and Spasms
Crohn's Disease
Cystic Breast Disease
Cystic Fibrosis
Dandruff
Debility
Dementia
Depression
Dermatitis
Diabetes
Diabetic Retinopathy
Erectile Dysfunction
Estrogen (low)
Fibroids (uterine)
Fibromyalgia Syndrome
Fibrosis
Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
Heart (weakness)
Hypertension
Hypothyroid
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Irritable Bowel Syndrome
Itching
Knees (weak)
Leaky Gut Syndrome
Leprosy
Lesions
Leukemia
Lou Gehrig's Disease
Lupus
Lymphoma
Melanoma
Memory and Brain Function
Menopause
Menstrual Irregularity
Mental Illness
Metabolic Syndrome
Migraine
Miscarriage (prevention)
Mood Swings
Multiple Sclerosis
Muscle Tone (lack of)
Muscular Dystrophy
Myasthenia Gravis
Nephritis
Nerve Damage
Nervous Exhaustion
Numbness
Nursing
Obsessive Compulsive Disorder
Oral Surgery
Osteoporosis
Pain (general remedies for)
Pancreatitis
Paralysis
Parkinson's Disease
Peripheral Neuropathy
PMS (general)
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pneumonia
Polyps
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prostatitis
Psoriasis
Rheumatoid Arthritis
Schizophrenia
Sciatica
Seasonal Affective Disorder
Senility
Acne
Allergies (respiratory)
Arteriosclerosis
Asthma
Anemia
Cardiovascular Disease
Fatigue
Tuberculosis