Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Monolaurin, a monoglyceride derived from lauric acid (found in coconut oil), has gained attention for its potential antiviral effects, particularly against lipid-coated viruses. The scientific justification for its use in supporting or treating colds is based mainly on in vitro studies rather than large clinical trials. Laboratory research demonstrates that monolaurin can disrupt the lipid membranes of various viruses, including some responsible for respiratory infections. This mechanism may theoretically inhibit viral replication or infectivity. However, most of this evidence is limited to laboratory (cell culture) studies and a few animal models. There is a lack of robust human clinical trials directly demonstrating monolaurin’s efficacy in preventing or treating the common cold (typically caused by rhinoviruses, which are not lipid-enveloped, though some cold-causing viruses are).

Despite its promising antiviral activity in the lab, the translation to clinical benefit in humans remains unproven. Some supplement manufacturers and anecdotal reports suggest monolaurin helps with cold symptoms, but these claims are not yet substantiated by high-quality clinical data. Therefore, while there is a plausible scientific rationale and preliminary evidence for monolaurin’s antiviral effects, its practical effectiveness for the common cold is still unconfirmed, meriting a low but nonzero evidence rating.

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