Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Ligustilides are naturally occurring phthalides found primarily in plants such as Angelica sinensis (Dong Quai) and Ligusticum chuanxiong, which are used in traditional Chinese medicine (TCM). In TCM, these herbs are often prescribed in formulations intended to "expel wind," "move qi," or support recovery from colds and flu-like symptoms. The traditional use is more focused on the overall plant extract rather than isolated ligustilides, and the claimed benefit is generally to support immune function or alleviate symptoms rather than serve as a direct antiviral agent.

Scientific research investigating ligustilides for direct antiviral effects, especially against cold viruses (such as rhinoviruses or coronaviruses), is minimal. Some in vitro studies suggest ligustilides may have anti-inflammatory or mild antimicrobial properties, but robust clinical evidence supporting their use as antivirals for colds is lacking. Most scientific work focuses on other pharmacological effects, such as neuroprotection, analgesia, or vasorelaxation. Thus, while there is a strong tradition of using ligustilide-containing plants for respiratory and cold-like symptoms, scientific validation for ligustilides themselves as antiviral agents is limited. The evidence rating is low (1/5), reflecting primarily traditional use with little scientific backing for this specific indication.

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