Evidence supporting the use of: Glycyrrhizinic acid
For the health condition: Colds (antiviral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycyrrhizinic acid, a major bioactive compound in licorice root (Glycyrrhiza glabra), has been traditionally used in several cultures for respiratory ailments, including coughs and colds. More recently, scientific research has explored its antiviral properties. In vitro studies have shown that glycyrrhizinic acid and its derivatives can inhibit the replication of several viruses, such as SARS-associated coronavirus, influenza A virus, and herpes simplex virus. The proposed mechanisms include interference with viral gene expression, modulation of immune responses, and inhibition of viral entry into cells.

However, robust clinical evidence in humans specifically for the common cold is limited. Most of the antiviral data comes from laboratory or animal studies, and few randomized controlled trials in humans have conclusively demonstrated efficacy against the viruses that typically cause the common cold (e.g., rhinoviruses, coronaviruses other than SARS, adenoviruses). Some preliminary studies suggest that glycyrrhizinic acid may reduce the severity or duration of viral infections, but the results are not consistent or strong enough to fully validate its use for colds.

In summary, the use of glycyrrhizinic acid as an antiviral agent has some scientific basis, especially in laboratory settings, but high-quality clinical evidence for its effectiveness in treating or supporting recovery from the common cold is weak. Therefore, the scientific support is moderate but not definitive.

More about Glycyrrhizinic acid
More about Colds (antiviral)

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Products containing Glycyrrhizinic acid

We currently have no products on Caring Sunshine that contain this ingredient.