Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aureobasidium pullulans is a yeast-like fungus known for producing β-glucans (notably, the AFO-202 strain), which have been investigated for their immunomodulatory properties. Scientific studies, primarily in vitro and in animal models, have shown that β-glucans from A. pullulans can stimulate various aspects of the immune system, including activation of macrophages, dendritic cells, and enhancement of NK cell activity. Some preliminary research suggests these actions may help the body mount a more effective response to viral infections, including those that cause the common cold (rhinoviruses, coronaviruses, etc.).

However, direct evidence supporting the use of A. pullulans β-glucans specifically for preventing or treating the common cold in humans remains limited. A few small clinical trials and observational studies have reported improved immune markers and potential reduction in upper respiratory tract infections among healthy adults and children, but these studies typically involve small sample sizes and lack robust, placebo-controlled designs. There is a plausible biological rationale, given the role of β-glucans in immune modulation, but the evidence is not yet strong enough for broad medical endorsement.

In summary, while there is a scientific basis and some early supportive evidence for the use of A. pullulans-derived β-glucans in enhancing immune response to viral infections, the clinical evidence for efficacy against common colds in humans is still emerging and warrants further high-quality research.

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