Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arabinogalactans, particularly those derived from the larch tree (Larix species), have been studied for their potential to support immune function and reduce the incidence or severity of upper respiratory tract infections, including the common cold. The primary scientific rationale is that arabinogalactans are non-digestible polysaccharides that can act as dietary fiber and prebiotics, potentially modulating immune responses via effects on gut microbiota and direct interactions with immune cells such as macrophages and natural killer cells.

Several clinical trials and in vitro studies suggest that arabinogalactans may enhance immune parameters, such as increasing the production of cytokines (e.g., interferon-gamma) and stimulating phagocytosis. A few small randomized controlled trials have examined larch arabinogalactan supplementation in healthy adults. For example, a study published in Current Medical Research and Opinion (2002) found that supplementation reduced the incidence of cold episodes. Another trial (Nutrition Journal, 2010) reported a modest reduction in the number of participants experiencing cold infections.

However, the quality of the evidence is limited by small sample sizes, short study durations, and potential conflicts of interest. Meta-analyses and large-scale trials are lacking, and the overall effect size appears modest. Thus, while there is some scientific evidence suggesting a potential benefit of arabinogalactans in supporting immune function and possibly reducing cold incidence, the evidence base is not robust, and further high-quality research is needed.

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