Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Berberine is a bioactive compound found in several plants, including Berberis species. Its use to support the circulatory system is primarily grounded in scientific research, particularly regarding its impact on cardiovascular health. Several clinical studies and meta-analyses have shown that berberine can help lower blood lipid levels (such as total cholesterol, LDL cholesterol, and triglycerides) and reduce blood pressure in people with metabolic syndrome and type 2 diabetes. Additionally, berberine has demonstrated the ability to improve endothelial function, which is crucial for maintaining vascular health.

Mechanistically, berberine is known to activate AMP-activated protein kinase (AMPK), an enzyme involved in cellular energy regulation, which may contribute to its beneficial effects on lipid and glucose metabolism. This is relevant to cardiovascular health because improved lipid and glucose profiles are associated with reduced risk of atherosclerosis and other circulatory system disorders.

However, while the evidence is promising and suggests a beneficial role for berberine in supporting certain aspects of circulatory system health, most studies to date have been relatively short in duration and often involved small sample sizes. More large-scale, long-term clinical trials are needed to fully establish its safety and efficacy for this purpose. Nonetheless, current evidence supports the use of berberine as an adjunct to diet and lifestyle interventions for cardiovascular health under medical supervision.

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Other body systems supported by berberine

Products containing berberine

Nature's Sunshine Berberine IR
Nature's Sunshine Detox Basics (Best used by 7/31/25)