Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Circulation (poor)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid found primarily in fish oils. Its use for supporting "poor circulation" is primarily based on scientific evidence regarding its effects on cardiovascular health and vascular function. EPA has been shown in multiple clinical studies to reduce triglyceride levels, decrease platelet aggregation, and exhibit anti-inflammatory effects, all of which can positively affect blood flow and vascular health. Meta-analyses indicate that EPA supplementation can lower the risk of major cardiovascular events, especially in high-risk populations. Additionally, EPA may improve endothelial function, which is critical for maintaining proper circulation, by increasing nitric oxide production and reducing oxidative stress in blood vessels.
However, while EPA’s benefits for cardiovascular health are well established, direct evidence for its use specifically in treating “poor circulation” (such as peripheral artery disease or chronic venous insufficiency) is more limited. The available clinical trials more often focus on endpoints like reduced risk of heart attack or stroke rather than direct improvements in peripheral circulation. Nonetheless, the mechanistic rationale and supportive data for improved vascular health make EPA a reasonable adjunct for individuals with compromised circulation, although it should not replace established treatments for circulatory disorders.
In summary, the use of EPA for supporting circulation is scientifically justified, with moderate evidence supporting its role in improving vascular function and reducing cardiovascular risk factors, but more direct studies on poor circulation are needed.
More about EPA (eicosapentaenoic acid)
More about Circulation (poor)
Other ingredients used for Circulation (poor)
acetyl l-carnitineajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
lingusticum wallichii
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
zanthoxylum
birch
polyphenols
purslane
yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Arjuna
Arginine Alpha Ketoglutarate
Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Asteracea
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
Atractylone
Bishop's Weed
Butea monosperma
Black galingale
berry
Bur-Reed
Bioflavonoids
Bee products
Buddha's Hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
Borneol
Coumarin
Centella triterpenes
Chinese Silkvine
Cinnamomum
Chinese Mountain Ant
Carqueja
Calycosin
Capsinoids
Codonopsis
Capillary Artemisia
Cyanidin
Curcuminoid
Citrus
Capsaicin
Catecholamine
Cowherb
Curcumen
Centella asiatica
Coca
Chocolate
Curcuma
Chestnut
Cinnamaldehyde
Costus
Carthamus
cola nut
Currant
Diallyl sulfide
Diosmin
Dismutase
Danshen
Dong Quai
Date
Diosmetin
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
epicatechin
Elk antler
Eicosapentaenoic Acid
Essential Oil Blend
Ephedrine
Ethylenediaminetetraacetic acid (EDTA)
Echium
Garlic
Mustard
Mistletoe
Pistachio
Sumac
Sweet Orange alcohol
yohimbine
Zucchini
Other health conditions supported by EPA (eicosapentaenoic acid)
Alzheimer's DiseaseAngina
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Autism
Bipolar Mood Disorder
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Cholesterol (high)
Circulation (poor)
Congestive Heart Failure
Depression
Diabetes
Dysmenorrhea
Endometriosis
Fatty Liver Disease
Hypertension
Inflammation
Inflammatory Bowel Disorders
Lupus
Memory and Brain Function
Migraine
Osteoporosis
Parkinson's Disease
Peripheral Neuropathy
PMS (general)
Psoriasis
Rheumatoid Arthritis
Stress
Strokes
Triglycerides (high)
Wounds and Sores