Evidence supporting the use of: Fish oil
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fish oil, rich in omega-3 fatty acids (EPA and DHA), has been studied for its potential to reduce certain side effects associated with chemotherapy, such as inflammation, cachexia (muscle wasting), and neuropathy. Scientific interest stems from the anti-inflammatory and immunomodulatory properties of omega-3s, which may help mitigate the inflammatory response and tissue damage induced by chemotherapy. Several small clinical trials and observational studies have explored fish oil supplementation in cancer patients undergoing chemotherapy, with some reporting benefits such as reduced weight loss, better maintenance of muscle mass, improved appetite, and decreased fatigue. Some evidence also suggests a possible protective effect against chemotherapy-induced peripheral neuropathy, though findings are inconsistent.

However, the overall quality of evidence is moderate to low. Many studies are small, heterogeneous, and vary in fish oil dosage and composition. Systematic reviews and meta-analyses note that while there is promise, the evidence is insufficient to make strong recommendations for routine use. Importantly, concerns have been raised that omega-3s could interfere with chemotherapy efficacy in certain contexts, though this remains controversial and not confirmed in large-scale clinical trials. There is no strong traditional or folkloric use of fish oil for chemotherapy support; its application in this context is based on modern biomedical research. In summary, while scientific rationale and some clinical evidence exist, the support is modest, and further high-quality research is needed to clarify benefits and risks.

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3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acemannan
AHCC
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Aloe vera
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caryophyllene
chamomile
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coix
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curcumin
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cyclodextrin
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dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
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grape
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herbal blend (proprietary)
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