Evidence supporting the use of: Selenium
For the health condition: Cervical Dysplasia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Selenium has been investigated as a supportive treatment for cervical dysplasia, primarily due to its role as an essential trace mineral with antioxidant properties. Scientific interest is based on the hypothesis that selenium, by enhancing antioxidant defenses, could help protect epithelial cells from oxidative DNA damage that contributes to the progression of cervical intraepithelial neoplasia (CIN), a precursor to cervical cancer. Some small clinical trials and observational studies have explored the association between selenium status and cervical dysplasia. For example, a randomized controlled trial published in 2018 (Biological Trace Element Research) found that selenium supplementation (200 mcg/day) for 6 months in women with CIN 1 was associated with a higher rate of lesion regression compared to placebo, potentially due to improved antioxidant status and modulation of inflammatory cytokines. However, other studies have produced mixed results, and systematic reviews conclude that while selenium may have a beneficial role, the evidence is still preliminary and larger, well-controlled trials are needed. Selenium is not a replacement for standard medical management of cervical dysplasia, and its use should be adjunctive and guided by healthcare professionals. Thus, while there is some scientific rationale and early supportive evidence, the overall strength of evidence is modest (rated 2/5), and selenium should not be considered a primary therapy for cervical dysplasia at this time.

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