Evidence supporting the use of: Vitamin B12
For the health condition: Carpal Tunnel Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 (cobalamin) has been investigated as a supportive treatment for Carpal Tunnel Syndrome (CTS), particularly in patients with confirmed B12 deficiency. The rationale stems from B12’s essential role in nerve health and myelin synthesis. Several small clinical studies and case reports suggest that B12 supplementation (often in its methylcobalamin form) may improve symptoms such as numbness, tingling, and pain in CTS, especially in early or mild cases. Notably, a few randomized, controlled trials have shown modest benefits in symptom relief and nerve conduction velocity improvements, but these trials often have limitations such as small sample sizes, short durations, or lack of blinding.

Mechanistically, vitamin B12 may facilitate nerve repair and reduce neuropathic symptoms, which is relevant given that CTS results from median nerve compression. However, most evidence supports B12 supplementation only in individuals who are deficient, as routine use in the general CTS population without deficiency does not have robust scientific backing.

In summary, while there is some scientific basis—mainly from small trials and mechanistic studies—for using vitamin B12 in CTS (especially in deficiency states), the overall evidence is limited and not definitive. Large, high-quality trials are lacking, so B12 is generally considered an adjunct rather than a primary therapy for CTS.

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Other ingredients used for Carpal Tunnel Syndrome

rosemary
selenium
vitamin B12
vitamin B6
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