Evidence supporting the use of: Hesperidin
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperidin is a flavonoid primarily found in citrus fruits, and it has been studied for its potential cardiovascular benefits. Scientific interest in hesperidin for cardiovascular disease (CVD) is based on its vascular-protective, anti-inflammatory, and antioxidant properties. Preclinical studies have shown that hesperidin can improve endothelial function, reduce blood pressure, and decrease low-density lipoprotein (LDL) oxidation, all of which are important factors in the development and progression of CVD.

Several clinical trials have been conducted, mostly small and short-term, indicating that hesperidin supplementation may improve vascular function and lower blood pressure in both healthy individuals and those at risk of CVD. A 2020 meta-analysis of randomized controlled trials found that hesperidin supplementation could result in a modest but statistically significant reduction in systolic blood pressure and improvement in endothelial function markers. Additionally, hesperidin appears to modulate lipid profiles by lowering total cholesterol and LDL cholesterol, although the effect sizes are relatively small.

However, the evidence base is not robust, with limitations including small sample sizes, variability in hesperidin dosages, and short study durations. While laboratory and animal studies provide mechanistic support, larger, high-quality human trials are needed to confirm hesperidin’s role in the prevention or treatment of cardiovascular disease. Thus, while there is scientific validation for the use of hesperidin in supporting cardiovascular health, the current evidence is moderate rather than definitive.

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