Tamarind (Tamarindus indica) has a long history of use in traditional medicine, including in the treatment of mouth ulcers or canker sores. In various folk medicine systems, particularly in South Asia, tamarind pulp or extracts are sometimes applied directly to mouth ulcers, or incorporated into rinses, with the belief that its acidic and astringent properties can help promote healing, reduce pain, or act as an antimicrobial agent. However, the traditional use is not universal, and it is more commonly documented in Ayurvedic and Unani medicine texts. From a scientific perspective, there is limited direct evidence supporting tamarind's efficacy specifically for canker sores. Some in vitro studies have demonstrated that tamarind extracts possess antimicrobial and anti-inflammatory properties, which could theoretically be beneficial for oral lesions. Nonetheless, no clinical trials or robust animal studies have evaluated tamarind as a treatment for aphthous ulcers or canker sores in humans. Therefore, while its use is rooted in traditional practices and supported by some plausible biological mechanisms, the evidence remains weak, and it has not been validated in clinical settings.