Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Pyridoxine (Vitamin B6) has a traditional basis for use in the management of canker sores (aphthous ulcers), but the scientific evidence supporting its effectiveness is limited and not robust. Historically, B vitamins—including B6—have been considered in the context of oral mucosal health because deficiencies in certain B vitamins (such as B12, folate, and occasionally B6) are associated with the development of oral sores. Some case reports and small studies from several decades ago suggested that B vitamin supplementation, including B6, could reduce the frequency or severity of canker sores, particularly in individuals with demonstrable deficiencies. However, these studies often lacked rigorous design, had small sample sizes, and did not isolate B6 as the sole factor. More recent reviews and clinical guidelines generally do not recommend routine use of B6 for canker sores unless a deficiency is present. Large, high-quality randomized controlled trials specifically evaluating pyridoxine supplementation for aphthous ulcers are lacking. Thus, while the use of B6 in this context is grounded in tradition and some plausible biological rationale—since B6 is important for mucosal health and immune function—the direct evidence is weak. Most modern sources emphasize correcting any underlying nutritional deficiencies, rather than supplementing with B6 as a standalone treatment for canker sores.

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