Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Neem (Azadirachta indica) has a long history of use in traditional Indian medicine (Ayurveda) for various oral health concerns, including canker sores (aphthous ulcers). Traditionally, neem twigs have been used as natural toothbrushes, and neem extracts or pastes have been applied to the oral mucosa to reduce pain and inflammation. The rationale is based on neem's well-documented antimicrobial, anti-inflammatory, and wound-healing properties, which are believed to help prevent secondary infection of ulcers and promote healing. However, while laboratory studies have shown neem extracts possess antibacterial and anti-inflammatory activity, there is limited direct clinical evidence specifically evaluating neem for canker sores in humans. Most studies focus on neem's effects on general oral health, such as reducing plaque, gingivitis, or oral bacteria. Anecdotal reports and traditional texts endorse neem's use for mouth ulcers, but rigorous clinical trials are lacking. Thus, neem's use for canker sores is primarily justified by tradition and supported by its general antimicrobial and anti-inflammatory effects. Scientific evidence specific to aphthous ulcers is sparse, so the rating is moderate (2/5), reflecting the gap between traditional endorsement and direct experimental validation.

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