Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus reuteri has some scientific backing for its use in supporting or treating canker sores (recurrent aphthous stomatitis). Several randomized controlled trials and clinical studies have investigated the effects of L. reuteri probiotics on the frequency, duration, and severity of canker sores. The primary mechanism proposed is the modulation of the oral microbiota, reduction of inflammation, and enhancement of mucosal healing. L. reuteri can produce reuterin, an antimicrobial substance that inhibits pathogenic bacteria, potentially reducing secondary infections that exacerbate canker sores.

A notable double-blind, placebo-controlled clinical trial published in the Journal of Clinical Periodontology (2013) found that daily administration of L. reuteri lozenges led to a statistically significant reduction in the number and duration of aphthous ulcers compared to placebo. Additional smaller studies have reported improvements in healing times and pain reduction, though results are not always consistent and sample sizes are often limited. A 2020 review article concluded that while there is encouraging preliminary evidence, more robust, large-scale trials are needed to confirm the benefit and optimal dosage.

In summary, L. reuteri is not a traditional remedy for canker sores, but there is moderate scientific support for its use, justifying a middle-level evidence rating. It is generally considered safe, and may be a helpful adjunct for individuals with recurrent aphthous ulcers, particularly for those interested in probiotic-based therapies.

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