Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Indigo leaves (Indigofera tinctoria) have traditionally been used in various folk medicine systems, including Ayurveda and Siddha, for the management of oral ailments such as canker sores (aphthous ulcers). The rationale for their use is primarily based on their purported anti-inflammatory, antimicrobial, and wound-healing properties. Traditional texts recommend the application of indigo leaf paste or rinse for soothing mouth ulcers and promoting healing.

Scientific validation for this use, however, is very limited. A small number of in vitro and animal studies have demonstrated that indigo leaves contain compounds like indirubin and indigo, which have anti-inflammatory and antimicrobial activities. However, there are no high-quality clinical trials in humans that specifically evaluate the efficacy of indigo leaves for the treatment of canker sores. Existing evidence is largely anecdotal or based on preliminary laboratory research, and there is a lack of standardized preparations or dosing guidelines for this purpose.

Overall, while the use of indigo leaves for canker sores is supported by a long history of traditional use, the scientific evidence is weak and not sufficient to recommend it as a first-line treatment. Caution should be exercised due to the potential for toxicity and allergic reactions, as some Indigofera species can be harmful if ingested in large amounts or used improperly.

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