Herbal blends have long been used in traditional medicine to soothe canker sores (aphthous ulcers). These blends commonly include ingredients such as chamomile, licorice root, sage, myrrh, and calendula—plants known for their anti-inflammatory, antimicrobial, and wound-healing properties. Traditional use is supported by centuries of anecdotal evidence, especially in European, Middle Eastern, and Asian herbal practices. For example, chamomile has been used as a mouth rinse for oral ulcers, and licorice root extracts have been included in gels and mouthwashes to alleviate pain and promote healing. Scientific studies on individual herbs (e.g., licorice, chamomile) indicate some benefit for reducing pain and healing time, but high-quality clinical trials on multi-herb "herbal blends" are rare and often of low methodological quality. Most evidence comes from small, short-duration studies or case reports. There is little consensus on ideal formulations, dosages, or mechanisms of action for these blends, and results may not be generalizable. Nevertheless, the traditional use of these herbs persists, and some individuals report symptomatic relief. In summary, the use of herbal blends for canker sores is primarily rooted in traditional practices, with limited but suggestive evidence for efficacy, especially for specific herbs. More rigorous clinical research is needed to validate their effectiveness and safety.