Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Calotropis gigantea, commonly known as crown flower, has a long history of use in traditional medicine systems, particularly in Ayurveda and folk medicine across Asia and Africa. It has been employed for a variety of ailments including skin conditions, digestive issues, and as an adjunct in the management of tumors and cancer. The traditional use of Calotropis gigantea for cancer is based on the belief that its latex and extracts possess cytotoxic properties that can inhibit tumor growth. However, while some preclinical studies (in vitro and in vivo) have indicated that extracts from Calotropis gigantea may have cytotoxic effects against certain cancer cell lines, there is a lack of robust clinical evidence in humans to support its efficacy or safety as a cancer therapy. The active compounds, such as cardenolides, flavonoids, and triterpenoids, have shown promise in laboratory settings, but these findings have not yet translated into clinical recommendations. Thus, its use is primarily justified by traditional use rather than solid scientific validation, and the level of evidence supporting its use for cancer is considered low (rated 2 out of 5), indicating preliminary experimental support but no clear clinical endorsement.

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