Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-Glutamine Use in Burns and Scalds: Scientific Evidence

L-glutamine is an amino acid that plays a key role in protein synthesis, immune function, and intestinal health. Its use in the management of burns and scalds is primarily supported by scientific rationale and clinical research rather than traditional or historical use.

Burn injuries are characterized by hypermetabolism, increased protein catabolism, and immunosuppression. These factors contribute to delayed wound healing, increased infection risk, and overall poorer outcomes. Several studies have investigated the benefits of glutamine supplementation in burn patients, focusing on its potential to improve immune function, preserve gut integrity, and enhance recovery.

Clinical trials and meta-analyses have shown that glutamine supplementation, particularly when administered enterally or parenterally, may reduce infection rates, decrease length of hospital stay, and improve nitrogen balance in burn patients. For example, a 2014 meta-analysis published in Burns found that glutamine supplementation was associated with reduced infectious complications and improved mortality rates in severely burned patients. Glutamine is thought to support the repair of the intestinal mucosa, reduce bacterial translocation, and modulate inflammation, all of which are beneficial during burn recovery.

However, while there is moderate scientific support, results are not universally consistent, and some studies have shown limited or no benefit. Guidelines often recommend considering glutamine supplementation in burn patients, especially those with extensive injuries, but emphasize the need for individualized assessment.

In summary, the use of L-glutamine for burns and scalds is justified by scientific evidence, but the overall strength of the evidence is moderate (rated 3/5).

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