Three-Leaf-Caper (Crateva religiosa, also known as Crateva nurvala) has a historical reputation in traditional medicine systems such as Ayurveda and folk medicine in parts of South Asia. Traditional healers have used various parts of the plant—including the leaves and bark—as poultices or topical preparations for skin ailments, including boils, abscesses, and other inflammatory skin conditions. The rationale in these traditional systems is likely related to the plant’s perceived anti-inflammatory and wound-healing properties. However, scientific evidence directly supporting the efficacy of Three-Leaf-Caper for boils is limited. Some laboratory studies have identified anti-inflammatory and antimicrobial properties in extracts of the plant, but these studies are generally preliminary, conducted in vitro or in animal models, and rarely focus specifically on boils or skin abscesses. There is a lack of robust clinical trials or pharmacological studies directly linking Three-Leaf-Caper to significant benefits in treating boils in humans. Therefore, while its use is rooted in tradition, the current scientific validation is minimal, and the evidence can be considered weak and indirect.