Phyllanthus species, particularly Phyllanthus niruri and related plants, have a long history of use in traditional medicine systems such as Ayurveda, Siddha, and folk medicine across South Asia. They are often applied topically or taken internally for skin conditions, including boils, which are localized skin infections characterized by pus-filled lumps. The rationale in traditional medicine for using Phyllanthus in boils typically centers on the herb’s reputed anti-inflammatory, antimicrobial, and detoxifying properties. Various ethnobotanical surveys and traditional pharmacopeias mention the use of Phyllanthus preparations (sometimes as a paste or decoction) for skin eruptions, abscesses, and similar infections. However, direct scientific studies specifically evaluating Phyllanthus species for the treatment or prevention of boils are lacking. Some in vitro research has shown that certain Phyllanthus extracts possess antibacterial activity against pathogens commonly implicated in skin infections, such as Staphylococcus aureus. Yet, this evidence is preliminary and does not directly translate to proven clinical efficacy for boils. Thus, while there is a traditional basis for this use and some indirect scientific rationale, robust clinical studies are absent, and the evidence is limited.