Evidence supporting the use of: Selenium
For the health condition: Blood Poisoning

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenium has been investigated for its potential role in the treatment of blood poisoning, also known as sepsis. Scientific interest in selenium stems from its role as a crucial component of antioxidant enzymes, particularly glutathione peroxidases, which help to reduce oxidative stress and inflammation—key factors in the pathophysiology of sepsis. Several clinical trials and meta-analyses have examined the effect of selenium supplementation in critically ill patients, including those with sepsis. Some studies suggest that high-dose intravenous selenium may reduce markers of oxidative stress, modulate the immune response, and potentially lower mortality rates in septic patients. For instance, a 2015 meta-analysis published in Critical Care reviewed randomized controlled trials and found that selenium supplementation could reduce all-cause mortality and the length of ICU stay, though the effect sizes were modest and results were not universally consistent across all studies.

However, not all research supports a clear benefit. Some large-scale randomized trials have shown no significant reduction in mortality with selenium supplementation in sepsis. Thus, while there is a scientific rationale and some supporting clinical evidence, results remain mixed and selenium is not universally recommended as a standard therapy for blood poisoning at this time. Ongoing research continues to explore optimal dosing, timing, and patient selection. Overall, the evidence supporting selenium’s use in blood poisoning is moderate, meriting a rating of 3 out of 5.

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