Greater Celandine (Chelidonium majus) has a long history of use in traditional medicine, including for the treatment of bites and stings. Historical herbal texts and folk remedies from Europe and Asia mention the topical application of Greater Celandine sap or poultices to soothe the skin after insect bites or stings, and sometimes even after snake bites. It was believed to possess anti-inflammatory and analgesic properties that could reduce pain, swelling, and irritation.

However, these uses are based on tradition rather than rigorous scientific evidence. There are very few, if any, clinical or laboratory studies that specifically examine Greater Celandine’s efficacy in treating bites or stings. Most scientific investigation into Greater Celandine has focused on its potential antispasmodic, antimicrobial, and hepatoprotective effects rather than dermatological or anti-venom properties. Some of its alkaloids have demonstrated mild antimicrobial and anti-inflammatory activity in vitro, but these findings are not specific to bites or stings and do not substantiate its traditional use for these conditions.

In summary, the use of Greater Celandine for bites and stings is supported by historical and ethnobotanical sources but lacks scientific validation. Given its potential for causing skin irritation or allergic reactions, topical use should be approached with caution.