Arani (Premna serratifolia), also known as "Agnimantha" in Ayurveda, has a long history of traditional use in Indian medicine, including for the treatment of bites and stings. Classical Ayurvedic texts such as the Charaka Samhita and Sushruta Samhita describe the use of Arani in various formulations intended to manage symptoms associated with bites from snakes, insects, and scorpions. The root and leaves are often used, either as pastes applied externally or as decoctions taken internally, with the aim of reducing swelling, pain, and toxicity.

While these uses are well documented in traditional medical literature, scientific validation is limited. Some phytochemical studies have identified the presence of flavonoids, alkaloids, and other bioactive compounds in Premna serratifolia that may have anti-inflammatory or analgesic properties. However, there is a lack of rigorous clinical trials or in vivo studies specifically evaluating its efficacy for bites and stings. The evidence supporting its use is therefore primarily traditional, with only preliminary pharmacological data suggesting possible mechanisms.

In summary, the use of Arani for bites and stings is strongly rooted in traditional medicine, but robust scientific evidence is lacking. Its current use for this indication in herbal practice is based more on historical precedent than on modern clinical research.