Evidence supporting the use of: Selenium
For the health condition: Athlete's Foot

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenium, particularly in the form of selenium sulfide, has scientific validation for its use in the topical treatment of certain fungal skin infections, including Athlete's Foot (tinea pedis). Selenium sulfide is more commonly recognized for its effectiveness against seborrheic dermatitis and tinea versicolor, but several studies and clinical guidelines note its antifungal properties may extend to dermatophyte infections like tinea pedis, which causes Athlete’s Foot. The mechanism of action is thought to involve inhibition of fungal cell growth by disrupting cell membrane integrity and interfering with enzyme systems containing sulfhydryl groups.

Topical selenium sulfide (usually as a 1% or 2.5% lotion or shampoo) is sometimes used off-label for tinea pedis, especially in cases where conventional antifungals (such as azoles or allylamines) are ineffective or not tolerated. Randomized controlled trials are limited, but small studies and case reports have shown positive outcomes, particularly for interdigital tinea pedis. For instance, a study published in the Journal of the American Academy of Dermatology (1984) demonstrated the efficacy of selenium sulfide lotion in the treatment of tinea pedis. However, it is not considered the first-line treatment and is not as broadly recommended as standard antifungal agents.

In summary, there is moderate scientific evidence supporting the topical use of selenium sulfide for Athlete’s Foot, but it is generally used as an alternative rather than a primary therapy. Its role is supported by both its known antifungal action and limited clinical data.

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