Evidence supporting the use of: Berberine
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Berberine, a bioactive alkaloid extracted from plants like Berberis species, has garnered scientific interest for its potential cardiovascular benefits, including in the context of arteriosclerosis (the thickening and hardening of arterial walls). Several preclinical and clinical studies have investigated berberine’s effects on lipid metabolism, endothelial function, and inflammation, all of which are relevant to arteriosclerosis. Berberine has been shown to reduce total cholesterol, LDL cholesterol, and triglyceride levels in humans, primarily by upregulating LDL receptor expression and influencing AMP-activated protein kinase (AMPK) activity. Additionally, it has antioxidant and anti-inflammatory properties, which may help counteract vascular injury and plaque formation.

Some small randomized controlled trials and meta-analyses suggest that berberine supplementation can improve lipid profiles and markers of endothelial function, both risk factors for arteriosclerosis. However, direct evidence for berberine preventing or reversing established arteriosclerosis in humans is limited. Most clinical studies focus on surrogate outcomes (e.g., blood lipids, inflammatory markers) rather than direct measures of arterial plaque or stiffness. The evidence base is still emerging, and larger, long-term studies are needed. Nonetheless, the mechanistic rationale and early human data provide moderate scientific support for berberine’s use as an adjunct in managing arteriosclerosis risk, particularly in individuals with dyslipidemia or metabolic syndrome.

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