Evidence supporting the use of: Magnesium
For the health condition: Anxiety
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Magnesium is commonly used as a supplement to support anxiety relief, and there is some scientific evidence to support this practice, although the quality and quantity of evidence are moderate. Magnesium plays a crucial role in nervous system function and regulation of neurotransmitters that influence mood, such as GABA. Low magnesium levels have been associated with symptoms of anxiety in both observational and some interventional studies. A 2017 systematic review (Boyle et al.) concluded that magnesium supplementation may have a beneficial effect on mild anxiety, but also highlighted that the studies were generally small and of low quality.
Mechanistically, magnesium appears to modulate the hypothalamic-pituitary-adrenal (HPA) axis and block the activity of N-methyl-D-aspartate (NMDA) receptors, which are involved in the stress response. Some randomized controlled trials have shown modest reductions in anxiety symptoms with magnesium supplementation, especially in individuals with magnesium deficiency or those under significant stress. However, other trials have shown minimal or no effect, leading to ongoing controversy about its efficacy.
In summary, while there is a plausible biological rationale and some scientific evidence supporting the use of magnesium for anxiety, the overall strength of the evidence is moderate at best (rated 2 out of 5). More rigorous, large-scale studies are needed to draw definitive conclusions.
Other ingredients used for Anxiety
5-Hydroxytryptophan (5-HTP)alpha-pinene
amino acids
ashwagandha
waterhyssop
basil
benegut perilla (proprietary)
bergamot
beta caryophyllene
bifidobacterium bifidum
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
bupleurum falcatum
California poppy
cannabis sativa oil
chamomile
Chinese salvia root
citrus oil
clove
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
epigallocatechin gallate (EGCG)
fennel
gardenia
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
guayusa
hemp oil
hops
Indian tinospora
inositol
jujube
kava root
kudzu
l-glycine
l-theanine
l-tryptophan
lactium casein decapeptide
lactobacillus brevis
lactobacillus fermentum
lactobacillus gasseri
lactobacillus helveticus
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lavender
lion's mane
lithium orotate
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phellodendron amurense
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhizome
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
spearmint leaf
sphaeranthus indicus
thyme
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
zinc
squawvine
catnip
gastrodia
cardamom
shen-chu
mugwort
anise
tinospora cordifolia
blackboard tree
peony
lingzhi
lemongrass
kanna
silk tree
chrysanthemum
ganoderma
sweet flag
oriental arborvitae
menthol oil
St. John's Wort
wood betony
hypothalamus
herbal blend (proprietary)
indigo leaves
cocoa
soursop
geranium
7,8-Dihydroxyflavone
Ash
Agastache
Alpha-terpineol
Ardisia
Agrimony
Apigenin
Anamu
Albizia
Aconite
Agmatine
Agarwood
Anemone
Alpha lactalbumin
Asteracea
Aniracetam
Amor seco
Betony
Black Seed
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Balsam
Bayleaf
Bacopin
Baicalein
Brahmi
Bacopa
Bee products
Bombax
Bacteria
Bifidobacteria
Bupleurum
bacoside
Baicalin
Borneol
Camellia sinensis
Centella triterpenes
Caryophyllene
Common Monkey Flower
Cinnamomum
Clary sage
Capillary Artemisia
Citron
Chinese Raisintree
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Capitate Valerian
Curcuma
Catuaba
Cowslip
Cannabidiol
Calamus
Clostridium butyricum
Convolvulus prostratus
Convolvulus Pluricaulis
Clerodendrum indicum
Canscora
Cannabigerol
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dragonhead
Erythrina
Essential Oil Blend
Eugenol
Glycine
jasmine
Lotus
Mimosa
Poppy
Rose
Spikenard
Sandalwood
Sweet Orange alcohol
Vervain
yohimbine
Other health conditions supported by magnesium
Abdominal PainAbscesses
Acid Indigestion
Addictions (drugs)
Addictions (general remedies for)
Adrenal Fatigue
Aging (prevention)
Alcoholism
Alkalosis
Allergies (respiratory)
Alzheimer's Disease
Angina
Anorexia
Anxiety
Anxiety Disorders
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Athletic and Exercise Aids
Attention Deficit Disorder
Autism
Autoimmune Disorders
Backache
Bipolar Mood Disorder
Birth Control (countering side effects)
Body Building
Body Odor
Boils
Broken Bones
Bronchitis
Bulimia
Calcium Deficiency
Calcium Deposits
Cancer Treatment (reducing side effects)
Canker Sores
Carbuncles
Cardiac Arrest
Cardiovascular Disease
Chest Pain
Cholesterol (high)
Circulation (poor)
Colon (atonic)
Constipation (adults)
Convulsions
Cramps (leg)
Cramps (menstrual)
Cramps and Spasms
Depression
Diabetes
Digestion (poor)
Dizziness
Dysmenorrhea
Emotional Sensitivity
Endurance (lack of)
Energy (lack of)
Epilepsy
Exercise
Fatigue
Fibromyalgia Syndrome
Gastritis
Headache (cluster)
Headache (general)
Headache (tension)
Hearing Loss
Heart (weakness)
Heart Fibrillation or Palpitations
Hypertension
Insomnia
Mental Illness
Migraine
Mood Swings
Muscle Tone (lack of)
Nerve Damage
Nervous Exhaustion
Nervousness
Neurosis
Numbness
Osteoporosis
Oxygen Deficiency
Pain (general remedies for)
Paralysis
Pets (supplements for)
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
Post Partum Depression
Post Partum Weakness
Post Traumatic Stress Disorder
Pregnancy (herbs and supplements for)
Progesterone (low)
Psoriasis
Restless Leg Syndrome
Rhinitis
Seasonal Affective Disorder
Seizures
Senility
Shock
Skin (dry and/or flaky)
Skin Care (general)
Sleep (restless and disturbed)
Stress
Sugar Cravings
Surgery (healing from)
Surgery (preparation for)
Tachycardia
Tension
Testosterone (low)
Tetanus
Thinking (cloudy)
Tics
Tinnitus
TMJ
Tooth Decay
Toxemia
Triglycerides (high)
Twitching
Wasting
Wheezing
Worry
Wounds and Sores
Products containing magnesium
Nature's Sunshine CleanStart Mild
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Hydrate
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AnxiousLess
Nature's Sunshine AnxiousLess
Nature's Sunshine Calcium-Magnesium (SynerPro)
Nature's Sunshine Calcium Plus Vitamin D
Nature's Sunshine Cellular Energy
Nature's Sunshine Chromium-GTF
Nature's Sunshine Coral Calcium
Nature's Sunshine Coral Calcium
Nature's Sunshine Fibralgia
Nature's Sunshine Free Amino Acids
Nature's Sunshine Gentle Move
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Magnesium
Nature's Sunshine Magnesium Complex
Nature's Sunshine Mega-Chel
Nature's Sunshine Mind-Max
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Sea Calcium (Nature's)
Nature's Sunshine Sunshine Heroes Whole Food Papayazyme
Nature's Sunshine Silver Shield BioGuard Hand & Body Cream
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Urinary Maintenance
Nature's Sunshine Urinary System
Nature's Sunshine VitaWave
