Evidence supporting the use of: Bupleurum falcatum
For the health condition: Anxiety

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Bupleurum falcatum, known as Chai Hu in traditional Chinese medicine (TCM), has been used for centuries in Asia as a component of herbal formulas intended to "soothe the liver" and address emotional disturbances such as irritability, stress, and symptoms that may align with what is now termed anxiety. Its use in TCM is primarily documented as part of complex formulas like Xiao Yao San, which is prescribed for mood regulation, emotional instability, and somatic symptoms associated with psychological distress. However, most of the traditional support is anecdotal or based on centuries-old medical texts, rather than controlled clinical studies.

Modern scientific research on Bupleurum falcatum’s direct effects on anxiety is limited and mostly preclinical. Some animal studies have suggested that saikosaponins, a group of compounds found in Bupleurum, may exert anxiolytic-like effects by modulating neurotransmitter systems, including serotonin and GABAergic pathways. However, robust human clinical trials are lacking, and evidence remains insufficient to conclude efficacy or safety for treating anxiety specifically. Most of the available data is either from animal models or from studies of combined herbal formulas rather than Bupleurum alone.

In summary, while Bupleurum falcatum is traditionally used to support emotional well-being and may possess biologically active compounds, the evidence supporting its use for anxiety in humans remains weak and primarily based on traditional usage rather than strong scientific validation.

More about bupleurum falcatum
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5-Hydroxytryptophan (5-HTP)
alpha-pinene
amino acids
ashwagandha
waterhyssop
basil
benegut perilla (proprietary)
bergamot
beta caryophyllene
bifidobacterium bifidum
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
bupleurum falcatum
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cannabis sativa oil
chamomile
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citrus oil
clove
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
epigallocatechin gallate (EGCG)
fennel
gardenia
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
guayusa
hemp oil
hops
Indian tinospora
inositol
jujube
kava root
kudzu
l-glycine
l-theanine
l-tryptophan
lactium casein decapeptide
lactobacillus brevis
lactobacillus fermentum
lactobacillus gasseri
lactobacillus helveticus
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lavender
lion's mane
lithium orotate
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phellodendron amurense
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhizome
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
spearmint leaf
sphaeranthus indicus
thyme
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
zinc
squawvine
catnip
gastrodia
cardamom
shen-chu
mugwort
anise
tinospora cordifolia
blackboard tree
peony
lingzhi
lemongrass
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silk tree
chrysanthemum
ganoderma
sweet flag
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menthol oil
St. John's Wort
wood betony
hypothalamus
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indigo leaves
cocoa
soursop
geranium
7,8-Dihydroxyflavone
Ash
Agastache
Alpha-terpineol
Ardisia
Agrimony
Apigenin
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Albizia
Aconite
Agmatine
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Centella triterpenes
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Citron
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Calea zacatechichi
Centella asiatica
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