Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phlorotannins are polyphenolic compounds found in brown seaweeds and have attracted attention for their antimicrobial properties. While not traditionally used as antibiotics, recent scientific studies, primarily in vitro, have demonstrated that phlorotannins exhibit antibacterial activity against a range of pathogenic bacteria, including Staphylococcus aureus, Escherichia coli, and some antibiotic-resistant strains. Mechanisms proposed include disruption of bacterial cell membranes, inhibition of biofilm formation, and interference with quorum sensing. Several studies published between 2015 and 2023 have explored these effects, with some reporting synergistic activity when phlorotannins are combined with conventional antibiotics, potentially enhancing antibiotic efficacy or reversing resistance.

However, the evidence is largely preclinical and based on laboratory assays. There are no completed human clinical trials evaluating phlorotannins as standalone alternatives to antibiotics, and their pharmacokinetics and safety profiles in humans remain under-researched. Thus, while scientific validation exists for their antimicrobial potential, the evidence is not yet strong or comprehensive enough to support clinical use as an antibiotic alternative. Further research, especially in vivo and clinical studies, is needed to establish efficacy, safety, and practical applications in human medicine.

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