Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactiplantibacillus plantarum is a well-studied probiotic bacterium that has shown promise as a supportive agent during or after antibiotic therapy, but it is not considered a direct alternative to antibiotics. The rationale for its use is primarily scientific. Multiple clinical and preclinical studies indicate that L. plantarum can help restore gut microbiota balance disrupted by antibiotics, reduce antibiotic-associated diarrhea, and potentially support immune function. For example, randomized controlled trials (RCTs) have demonstrated that certain strains of L. plantarum can decrease the incidence and severity of diarrhea in patients receiving antibiotics (Johansson et al., 2015; McFarland et al., 2018). Mechanistically, L. plantarum is known to outcompete pathogenic bacteria, produce antimicrobial substances (like plantaricin), and modulate host immune responses.

However, the evidence for using L. plantarum as an actual alternative to antibiotics—meaning as a primary treatment for bacterial infections—is limited. Most research supports its adjunctive use: maintaining gut health during antibiotic treatment or preventing complications such as Clostridioides difficile infection. There is ongoing preclinical research into the direct antibacterial effects of L. plantarum, but as of now, it should not replace antibiotics in the treatment of acute bacterial infections. In summary, L. plantarum is scientifically validated as a supportive agent during antibiotic use, but not as a direct alternative.

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