Honey has been used traditionally for centuries as a remedy for wound healing and infections, and recent scientific research has validated some of these uses, particularly in the context of its antimicrobial properties. Several studies have demonstrated that certain types of honey, such as Manuka honey, possess significant antibacterial activity against a range of pathogens, including antibiotic-resistant strains like Staphylococcus aureus (MRSA). The antimicrobial effects are attributed to honey’s high sugar content, low pH, hydrogen peroxide production, and unique phytochemical components (e.g., methylglyoxal in Manuka honey).

Clinical evidence supports the use of honey as a topical treatment for infected wounds, burns, and ulcers, where it can serve as an adjunct or alternative to conventional antibiotics, particularly when antibiotic resistance is a concern. Systematic reviews and randomized controlled trials have found honey to be effective in promoting wound healing and reducing infection rates, though efficacy can vary depending on the type of honey and the condition treated.

However, the use of honey as a systemic alternative to oral or intravenous antibiotics for internal infections is not supported by robust clinical evidence. Thus, while honey is scientifically validated as an adjunct or alternative for topical infections and wound care, it is not a substitute for antibiotics in treating systemic bacterial infections.