Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Calotropis gigantea, also known as crown flower, has a long history of use in traditional medicine systems, particularly in Ayurveda and folk medicine across South and Southeast Asia. Its latex, leaves, bark, and roots have been used as remedies for a variety of ailments, including infectious diseases. Traditionally, different parts of the plant have been applied topically or ingested to treat skin infections, wounds, and respiratory conditions believed to be caused by microbial agents. However, the use of Calotropis gigantea as an alternative or adjunct to antibiotics is primarily based on ethnobotanical knowledge rather than robust clinical evidence.

Scientific investigations have demonstrated that extracts of Calotropis gigantea possess some in vitro antibacterial activity against a range of pathogens, including Staphylococcus aureus and Escherichia coli. These effects are attributed to phytochemicals such as cardenolides, flavonoids, and triterpenoids present in the plant. Despite these findings, the studies are mostly preclinical, limited to laboratory experiments, and lack translation to clinical efficacy in humans. Additionally, concerns exist regarding the plant’s toxicity, especially with improper preparation or dosing.

In summary, the use of Calotropis gigantea for infections or as an alternative to antibiotics is justified more by traditional practices than by scientific validation. Current evidence does not support its routine use as a substitute for antibiotics, and more rigorous clinical research is needed to determine its safety and efficacy in this context.

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