Synopsis

Source of validity: Scientific
Rating (out of 5): 2

10-Hydroxy-2-decenoic acid (10-HDA) is a unique fatty acid primarily found in royal jelly, the secretion produced by honeybees. Its potential as an alternative or adjunct to antibiotics has been investigated due to increasing interest in natural antimicrobial agents. Several in vitro studies have demonstrated that 10-HDA exhibits antimicrobial activity against a variety of bacteria, including some Gram-positive and Gram-negative strains. The proposed mechanisms include disruption of bacterial cell membranes and inhibition of biofilm formation. However, while these findings are promising, the majority of the evidence is limited to laboratory (in vitro) settings, and there is a lack of robust clinical trials in humans evaluating its efficacy in treating bacterial infections or as a direct substitute for antibiotics.

Moreover, while 10-HDA is a component of royal jelly, which has a history of traditional use for general health and vitality, its application specifically as an antibiotic alternative is based predominantly on recent scientific research rather than longstanding traditional practice. Systematic reviews and clinical studies are sparse, and there are concerns about effective dosing, bioavailability, and safety in humans. Therefore, while there is some scientific rationale for its antimicrobial properties, the evidence base for its use as a clinical alternative to antibiotics is currently weak and does not support widespread medical application outside of experimental or supplementary contexts.

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