Evidence supporting the use of: Vitamin B12
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 is used to support or treat Alzheimer's Disease primarily based on scientific reasoning, though the strength of evidence is limited. B12 deficiency can cause neurological symptoms resembling dementia, including memory loss, confusion, and cognitive decline. Correction of deficiency with B12 supplementation can reverse these symptoms in deficient individuals. Epidemiological studies have found that low B12 levels are more common in older adults and may be associated with an increased risk of cognitive decline and dementia, including Alzheimer's Disease. Additionally, B12 plays a role in homocysteine metabolism; elevated homocysteine is a risk factor for cognitive impairment and Alzheimer's, and B12 supplementation can help lower homocysteine levels.

However, controlled clinical trials in people with Alzheimer's Disease or mild cognitive impairment (MCI) have not consistently shown that B12 supplementation improves cognitive function in those without clear deficiency. Most guidelines suggest screening for and correcting B12 deficiency in patients with cognitive impairment, but do not recommend B12 supplementation for all Alzheimer's patients. The evidence is strongest for individuals who are deficient in B12, while routine use as a treatment for Alzheimer's in those with normal B12 levels is not supported by robust evidence. Thus, while there is a scientific rationale and limited evidence supporting B12 supplementation in deficient individuals, its role as a general treatment for Alzheimer's Disease is not well established.

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Other ingredients used for Alzheimer's Disease

acai berry
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akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
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chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
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quercetin
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resveratrol
rhizome
rosemary
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selenium
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tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
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vinpocetine
vitamin B
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vitamin C
vitamin D
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vitamin E
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