Evidence supporting the use of: Selenium
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Selenium is a trace mineral with antioxidant properties, and its role in aging and age-related diseases has been the subject of scientific investigation. Selenium is a cofactor for the enzyme glutathione peroxidase, which helps protect cells from oxidative damage by neutralizing free radicals. Since oxidative stress is a known contributor to the aging process and the development of age-related conditions, selenium has been hypothesized to have anti-aging benefits. Some population studies have observed that individuals with higher selenium status tend to have better cognitive function and may experience lower rates of age-related diseases, such as cardiovascular disease and certain cancers.

However, the evidence supporting selenium supplementation specifically for the prevention of aging in healthy adults is limited and mixed. Large randomized controlled trials, such as the SELECT trial, have not shown clear benefits of selenium supplementation in reducing the risk of major age-related diseases in well-nourished populations. There is also evidence that both selenium deficiency and excess can be harmful, and the margin between optimal and excessive intake is narrow. While selenium is essential for health and its deficiency can accelerate aging-related decline, supplementation beyond dietary needs does not have robust evidence for preventing aging itself. Thus, while there is a scientific rationale and some supporting data, the overall quality of evidence is low to moderate.

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