Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Berberine, a bioactive compound extracted from various plants such as Berberis vulgaris, has garnered attention for its potential benefits in treating acne. The scientific foundation for its use primarily stems from its antimicrobial, anti-inflammatory, and metabolic effects. Several in vitro studies have demonstrated berberine's ability to inhibit the growth of Propionibacterium acnes (now known as Cutibacterium acnes), a key bacterium implicated in the pathogenesis of acne. Additionally, berberine exhibits anti-inflammatory properties by modulating pathways such as NF-κB, which may help reduce the inflammation characteristic of acne lesions.

Some small clinical trials and pilot studies offer preliminary evidence. For instance, a 2012 randomized controlled trial involving adolescents with moderate to severe acne reported that oral berberine supplementation, as part of a herbal formula, led to significant improvements in acne severity over 4 weeks. The mechanism is believed to involve both direct antimicrobial action and improvement of insulin sensitivity, which can be relevant for individuals whose acne is associated with insulin resistance (as in polycystic ovary syndrome).

However, the overall quality and quantity of human evidence remain limited, and large-scale, well-controlled clinical trials are lacking. Thus, while there is some scientific basis for using berberine in acne, the evidence is not robust, and its use should be considered experimental pending further research.

More about berberine
More about Acne

Other ingredients used for Acne

Other health conditions supported by berberine

Products containing berberine

Nature's Sunshine Berberine IR
Nature's Sunshine Detox Basics