Evidence supporting the use of: Vitamin B6
For the health condition: Stress

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is sometimes used to support or treat stress, largely based on its role in neurotransmitter synthesis and regulation of homocysteine metabolism. Scientifically, vitamin B6 is essential for the biosynthesis of neurotransmitters such as serotonin, dopamine, and GABA, all of which are implicated in mood regulation and stress response. Several observational studies have found associations between low levels of B6 and increased symptoms of depression and anxiety, both of which are closely linked to stress. However, evidence from randomized controlled trials specifically evaluating B6 supplementation for stress reduction in healthy individuals is limited and mixed.

Some studies suggest that supplementation with B6, often in combination with other B vitamins or magnesium, may help reduce perceived stress or improve mood in certain populations, such as those with pre-existing deficiencies or premenstrual syndrome (PMS). For instance, a few trials have reported mild improvements in mood and stress levels in women with PMS when supplemented with B6. Nevertheless, these benefits are generally modest, and it is unclear whether B6 alone provides significant stress-relieving effects in the general population.

Overall, while there is a plausible biological mechanism for B6’s involvement in stress and some supportive evidence, the scientific validation is not robust, and high-quality clinical trials are lacking. Thus, the evidence supporting the use of vitamin B6 specifically for stress management is weak to moderate (rated 2/5).

More about vitamin B6
More about Stress

Other ingredients used for Stress

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
7-Keto-DHEA
Acetyl L-carnitine
Acetyl-L-Tyrosine
Agarwood
Agastache
Agmatine
Agrimony
Akebia
Albizia
Algal protein
Alpha lactalbumin
alpha-pinene
AMP-activated protein kinase (AMPK)
anemarrhena asphodeloides
anise
Anserina
antler
Antrodia camphorata
apigenin
Aralia
Arginine aspartate
arjun tree
arjuna
ashitaba
ashwagandha
asparagus
astragalus
baccosides
Bacopa
Bacopin
bacoside
baicalein
baicalin
Baikal Skullcap
banana
banyan
Basidiomycota
bee pollen
benegut perilla (proprietary)
bergamot
betony
Bifidobacteria
Bifidobacterium bifidum
Bifidobacterium lactis
Bifidobacterium longum
biota seed
bird\'s nest
black ginger
Black spruce
black tea
bonito peptide
borage
brahmi
Buddha\'s hand
Bupleurum
bupleurum falcatum
C-phycocyanin
calamus
Calea zacatechichi
California poppy
Canscora
Capitate Valerian
cardamom
caterpillar mushroom
catnip
catuaba
Celastrus
Centella asiatica
Centella triterpenes
chaga mushroom
chamomile
cherimoya
Chinese fleeceflower
Chinese mountain ant
chocolate
chuchuhuasi
Clary sage
Clerodendrum phlomidis
coca
cocoa
Codonopsis
Convolvulus pluricaulis
Convolvulus prostratus
cordyceps
coriander
corktree
Corydalis
cowslip
curcumin
Cymbopogon martini
cypress
damiana
date
devil\'s club
DHA (docosahexaenoic acid)
dibenzo-alpha pyrones
dismutase
dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
dodeca-2E, 4E-dienoic acid isobutylamide
dong quai root
eleuthero
emblicanin
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
Eplotab
Erythrina
Eurycoma Longifolia
Ficus religiosa
fish
fish protein
flavones
fo-ti
fragrant rosewood
frankincense
Fumaria parviflora
GABA (gamma aminobutyric acid)
galactooligosaccharides
gardenia
gastrodin
Gelsemium
Ginsenosides
Glycine
goji berry
goldthread
gotu kola
green tea
Griffonia simplicifolia
guayusa
gum
heartwood
Hemidesmus
hericium mushroom
hibiscus
Homalomena
honeybush
Honokiol
hops
Hypericum
isoliquiritigenin
Japanese kadsura
jasmine
Jatamansi
jiaogulan
jujube
jujubosides
kanna
kava
kavalactones
kola nut
kuding tea
kudzu
Kukicha
L-ornithine
L-taurine
L-theanine
L-tryptophan
l-tyrosine
lactalbumin
lactiplantibacillus plantarum
lactium casein decapeptide
Lactobacillus brevis
Lactobacillus casei
Lactobacillus helveticus
Lactococcus rhamnosus
Lactucarium
Lactucopicrin
Large-leaved linden
Lavandin
lavender
lemon balm
Lentinula edodes mycelia
Leptadenia
limonene
linden
lingzhi
lion's mane
liquid liver fractions
longan
lotus
lupulinum
Lycium
maca
macaenes
macamides
magnesium
magnolia
magnolol
mandarin
mangiferin
maral root
Marjoram
Matcha
Mate
Meadow sage
Melatonin
Mentha haplocalyx
Mesembrine
Methylxanthine
Mimosa
Mimulus
Mint
Mistletoe
Monkey flower
Motherwort
Muira puama
Mulberry
Mulungu
Mung bean
Myrcene
Nardostachys
Night jessamine
noni
Nymphaea caerulea
oat
oolong tea
orchid
oriental arborvitae
Oxindole alkaloids
passionflower
Passionfruit
Patchouli oil
Pentatropis capensis
Pepper Bark Tree
Peppermint
perilla
phosphatidylserine
phospholipids
pine bark
Piper chaba
Pistachio
Polygala
polygala root
poppy
pregnenolone
Purple Monkeyflower
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quail egg
Rauvolfia
Rehmannia
relora® (proprietary)
Rhodiola
Rooibos
Rosabin
rosavins
rose
rose oil
Safed musli
saffron
Safranal
Salidroside
Sandy Everlasting
Sarivan
sarsaparilla
sceletium
Schisandrins
Schizandrol A
Scleranthus annus
Semecarpus anacardium
sesame
Shankhpushpi
Shataverins
Shilajit
Sida cordifolia
silk tree
skullcap
spearmint leaf
Speedwell
Spikenard
spinach
St. John's Wort
Stachytarpheta cayennensis
star of Bethlehem
suma
Sumbul
Sweet Woodruff
Tagara
Taurine
Taxillus chinensis
Tetracyclic oxindole alkaloids
Tetrahydropalmatine
Traveler's Joy
Trichilia catigua
Trichopus zeylanicus
Uncaria
Valerenic acid
Valerian root
Vanilla
velvet bean
Verbena
Vetiver
Viburnum
Vine tea
vitamin B12
vitamin B6
Vitexin
Waterhyssop
whole adrenal glandular
Withanolides
Wogonin
Wood betony
Xanthine
Xanthone
Xanthophyll
Xylaria nigripes
Yellow-Fruit Nightshade
Yerba mate
Ylang ylang
Yohimbine
Yumberry
Yuzu
Zinc

Products containing vitamin B6

Nature's Sunshine Love and Peas (Sugar Free Original Formula)
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas (Sugar Free) NEW!
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens Pouch
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal Chocolate
Nature's Sunshine Power Meal Vanilla
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave