Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sceletium, commonly known as Sceletium tortuosum or "kanna," is a South African succulent traditionally used by indigenous peoples for mood enhancement and stress relief. Its primary active compounds are mesembrine alkaloids, which have been shown in preclinical studies to interact with the brain’s neurotransmitter systems, particularly the serotonin reuptake pathway. Animal and in vitro studies suggest that Sceletium extracts act as selective serotonin reuptake inhibitors (SSRIs), potentially increasing serotonin levels in the brain. Some small-scale human studies and open-label trials have reported improvements in mood, anxiety, and cognitive flexibility after Sceletium supplementation. However, large, well-controlled clinical trials are lacking, and the strength of evidence is moderate at best.

The traditional use of Sceletium was primarily for mood elevation and social relaxation, aligning with its observed effects on the neurotransmitter system in modern research. The available scientific validation supports its influence on neurotransmitters, especially serotonin, but more rigorous research is needed to fully substantiate its efficacy and safety. Overall, Sceletium is used to support the neurotransmitter system based on both its traditional use and emerging scientific evidence, though the latter is still developing.

More about sceletium
More about Specific Neurotransmitters

Other ingredients that support Specific Neurotransmitters

Other body systems supported by sceletium

Products containing sceletium