Evidence supporting the use of: Vitamin D3
For the body system: Small Intestines

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) is primarily known for its role in calcium homeostasis and bone health. However, there is some scientific evidence that vitamin D3 also impacts the small intestine, particularly in the regulation of calcium and phosphate absorption. The small intestine is the primary site where dietary calcium is absorbed, a process that is significantly enhanced by active vitamin D3 (calcitriol). This mechanism is well-documented and underpins the rationale for vitamin D3 supplementation in conditions like osteoporosis and rickets, where improved calcium absorption is desired.

Beyond mineral absorption, limited evidence suggests that vitamin D3 may influence the integrity of the intestinal barrier and modulate local immune responses. Some preclinical studies and small human trials indicate that vitamin D receptors are present in the intestinal epithelium, and deficiency has been associated with an increased risk of inflammatory bowel diseases (IBD) such as Crohn’s disease. However, direct benefits of vitamin D3 supplementation specifically for general small intestine health, outside of calcium absorption and certain disease conditions, are not well-established.

In summary, while there is scientific validation for the role of vitamin D3 in supporting the small intestine’s function in mineral absorption, evidence for broader benefits on small intestine health or function is limited. Therefore, the level of evidence is rated as 2 out of 5.

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