Trace minerals, such as zinc, copper, manganese, selenium, and boron, are scientifically recognized as important for the maintenance and development of the skeletal system. These minerals act as cofactors for enzymes involved in bone formation and remodeling. For example, zinc is essential for bone tissue growth and mineralization, copper is involved in cross-linking collagen and elastin in bone matrix, and manganese is required for the synthesis of proteoglycans necessary for bone structure. Boron has been shown to influence the metabolism of calcium, magnesium, and vitamin D, all of which play critical roles in bone health.

Numerous studies, both in animals and humans, support the role of these trace elements in maintaining healthy bone density and strength. Deficiencies in certain trace minerals have been linked to increased risk of osteoporosis and impaired bone healing. However, the majority of evidence supports the role of trace minerals as part of a balanced diet rather than as high-dose supplements. While calcium and vitamin D remain the primary nutrients for skeletal health, scientific consensus acknowledges that trace minerals are necessary for optimal bone metabolism and health, justifying their inclusion in support of the skeletal system.