Evidence supporting the use of: Magnesium
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Magnesium plays a crucial role in skeletal health, and its use to support the skeletal system is well-supported by scientific evidence. Approximately 60% of the body's magnesium is stored in bone, where it contributes to bone structure and strength. Magnesium is involved in bone formation directly, influencing the activity of osteoblasts (cells that build bone) and osteoclasts (cells that break down bone). It also regulates the levels of parathyroid hormone and the active form of vitamin D, both of which are essential for maintaining calcium balance and bone health. Clinical and epidemiological studies have found that low magnesium intake is associated with lower bone mineral density and an increased risk of osteoporosis and fractures, particularly in older adults. Supplementation with magnesium in deficient individuals has shown improvements in bone density. However, the effect is less pronounced in individuals who already have adequate magnesium intake. The scientific consensus is that adequate magnesium is important for bone health, and deficiency can compromise skeletal integrity, though it is not a stand-alone treatment for osteoporosis. Overall, the evidence base is robust, with numerous studies and reviews supporting the role of magnesium in maintaining healthy bones.

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