Evidence supporting the use of: Magnesium
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium is scientifically recognized as playing a role in supporting the serotonin system in the body, though the strength of evidence is moderate. Magnesium acts as a cofactor in the synthesis of serotonin, a neurotransmitter involved in mood regulation, sleep, and other bodily functions. Specifically, magnesium is necessary for the conversion of tryptophan to 5-hydroxytryptophan (5-HTP), a precursor to serotonin. Several observational studies have found associations between low magnesium levels and increased risk of depressive symptoms, which are thought to be partly linked to serotonin dysfunction. Some small randomized controlled trials suggest that magnesium supplementation can improve mood and reduce depressive symptoms, potentially via effects on serotonin pathways. However, most of these studies are limited in size and quality, and establishing a direct causal relationship between magnesium supplementation and increased serotonin levels in humans remains an area of ongoing research. Systematic reviews generally conclude that while there is biological plausibility and some clinical support, more robust, large-scale trials are needed to confirm the efficacy of magnesium for directly supporting the serotonin system. In summary, magnesium’s use to support the serotonin body system is scientifically plausible and supported by moderate evidence, especially in populations with magnesium deficiency.

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