Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eicosapentaenoic acid (EPA), an omega-3 fatty acid primarily found in fish oil, has scientific evidence supporting its use as an adjunctive therapy in rheumatoid arthritis (RA). Clinical trials and meta-analyses have demonstrated that EPA supplementation can modestly reduce joint pain, morning stiffness, and the number of tender joints in individuals with RA. The mechanism of action is believed to involve the anti-inflammatory properties of EPA, which can lead to decreased production of pro-inflammatory eicosanoids (such as prostaglandins and leukotrienes) derived from arachidonic acid. EPA also appears to modulate immune function by influencing cytokine production and cell membrane composition in immune cells. Several randomized controlled trials have shown that regular supplementation with fish oil (providing both EPA and DHA) can reduce the need for nonsteroidal anti-inflammatory drugs (NSAIDs) in RA patients, improve patient-reported pain scores, and in some cases improve physical function. However, while statistically significant, these effects are generally modest and EPA is not considered a replacement for disease-modifying antirheumatic drugs (DMARDs). Guidelines from professional organizations such as the American College of Rheumatology recognize that omega-3 fatty acid supplementation may provide symptomatic benefit for some patients with RA. In summary, the scientific evidence supporting the use of EPA for RA is moderate, justifying a rating of 3 out of 5.

More about EPA (eicosapentaenoic acid)
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Other ingredients used for Rheumatoid Arthritis

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Nature's Sunshine Circulatory System
Nature's Sunshine DHA
Nature's Sunshine Krill Oil (With Vitamin K2)
Nature's Sunshine Super Omega 3 EPA
Nature's Sunshine Super Omega 3 EPA
Nature's Sunshine Super Trio