Evidence supporting the use of: Folate
For the health condition: Pregnancy (herbs and supplements for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Folate (also known as vitamin B9) is strongly supported by scientific evidence for use during pregnancy. Adequate folate intake is crucial in the periconceptional period and throughout pregnancy, as it plays a vital role in DNA synthesis, cell division, and fetal growth. The most well-established benefit of folate supplementation is the prevention of neural tube defects (NTDs), such as spina bifida and anencephaly. Numerous large-scale studies and randomized controlled trials have shown that women who consume sufficient folate before conception and during early pregnancy substantially reduce their risk of having babies with NTDs. As a result, health authorities including the Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO), and the American College of Obstetricians and Gynecologists (ACOG) universally recommend that women of childbearing age take a daily folic acid supplement (the synthetic form of folate), typically at least 400 micrograms per day.

Beyond NTD prevention, folate is involved in maternal red blood cell production and may reduce the risk of other congenital anomalies, preterm birth, and low birth weight. Folate is found naturally in leafy greens, legumes, and fortified foods; however, supplementation is considered necessary for reliable prevention of deficiencies and associated risks. The evidence supporting folate’s role in pregnancy is robust, and its use is a standard of care worldwide.

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