Evidence supporting the use of: Folate
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folate, also known as vitamin B9, plays a crucial role in cellular division, DNA synthesis, and repair, which are essential processes in the ovaries, particularly during oogenesis (the development of egg cells). Scientific validation for folate’s role in supporting ovarian health primarily comes from its established importance in reproductive health and fertility. Numerous studies have shown that adequate folate intake is associated with improved fertility outcomes in women. Folate deficiency has been linked to menstrual irregularities, impaired oocyte quality, and increased risk of neural tube defects in the offspring, which highlights its centrality in preconception and early pregnancy care.

Furthermore, folate supplementation is routinely recommended for women of reproductive age, especially those planning to conceive, to decrease the risk of birth defects and support healthy ovarian function. Some research suggests that folate may also help reduce the risk of ovulatory infertility. While most evidence centers on folate’s role in preventing neural tube defects, its underlying mechanisms—such as supporting DNA methylation and synthesis—are directly relevant to ovarian cell function and overall reproductive health. Thus, the scientific basis for using folate to support the ovaries is strong, though its effects are most pronounced in the context of fertility and early development rather than as a direct treatment for ovarian disorders.

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