Relationship: Osteoporosis and manganese

Evidence supporting the use of: Manganese
For the health condition: Osteoporosis

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Source of validity: Scientific
Rating (out of 5): 2

Manganese is an essential trace mineral involved in bone formation, metabolism, and overall skeletal health. Its role in bone health is primarily due to its function as a cofactor for enzymes involved in the synthesis of proteoglycans, which are important components of bone matrix. Several observational and animal studies have shown that manganese deficiency can lead to impaired bone formation and decreased bone mineral density. Additionally, manganese is a component of the antioxidant enzyme superoxide dismutase (MnSOD), which may play a protective role in bone cells by reducing oxidative stress, a factor implicated in osteoporosis. However, there is limited direct clinical evidence that manganese supplementation alone can prevent or treat osteoporosis in humans. Most studies and clinical trials on osteoporosis focus on calcium, vitamin D, and sometimes magnesium, but manganese is rarely studied as a primary intervention. Some research has evaluated multinutrient supplements containing manganese, finding modest benefits for bone markers, but it is difficult to isolate manganese’s specific effect. Overall, while there is clear biological plausibility and a scientific rationale for manganese’s role in bone health, and deficiency should be avoided, there is insufficient high-quality clinical evidence to strongly support manganese supplementation as a treatment for osteoporosis. Thus, its use is scientifically plausible but not robustly supported by clinical trials, leading to a moderate evidence rating.

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Evidence supporting the use of: Manganese
For the health condition: Osteoporosis

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Other ingredients used for Osteoporosis

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Health concerns

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Evidence supporting the use of: ManganeseFor the health condition: Osteoporosis

Table of Contents

Synopsis

Other ingredients used for Osteoporosis

Other health conditions supported by manganese

Products containing manganese

Evidence supporting the use of: Manganese
For the health condition: Osteoporosis