Evidence supporting the use of: Hesperidin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperidin, a flavonoid abundantly found in citrus fruits, has been investigated for its potential benefits in bone health, including the prevention and treatment of osteoporosis. Preclinical studies, primarily in animal models and in vitro experiments, have shown that hesperidin can positively influence bone metabolism. Mechanistically, hesperidin appears to promote osteoblast (bone-forming cell) activity while inhibiting osteoclast (bone-resorbing cell) differentiation, possibly through modulation of oxidative stress and inflammatory pathways. For example, studies in ovariectomized rats (a common model for postmenopausal osteoporosis) demonstrated that hesperidin supplementation improved bone mineral density and bone microarchitecture compared to controls. Additionally, hesperidin’s antioxidant properties may help mitigate oxidative stress, which is implicated in the pathogenesis of osteoporosis. Despite these promising findings, clinical evidence in humans is limited. Few, if any, randomized controlled trials have directly assessed hesperidin's efficacy for osteoporosis in human subjects. Thus, while there is a scientific rationale and some experimental support for hesperidin’s use in osteoporosis, the evidence is not robust enough to warrant strong recommendations, and more high-quality clinical research is needed. Consequently, current support for hesperidin in osteoporosis is based largely on experimental data rather than established clinical practice.

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Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
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vitamin C
vitamin D
vitamin D3
vitamin K
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